Eosinophilic Gastrointestinal Diseases (EGIDs) and the Lungs 

Eosinophilic Gastrointestinal Diseases (EGIDs) are chronic conditions caused by high levels of eosinophils in the digestive tract, leading to inflammation and digestive symptoms such as abdominal pain, vomiting, and difficulty swallowing. Research increasingly shows a strong gut–lung connection, with many people with EGIDs also experiencing respiratory symptoms like asthma, wheezing, or chronic cough.

Around 5% asthma patients have severe (eosinophilic) asthma. Understanding the link between EGIDs and lung health is essential for early diagnosis, comprehensive care, and improving quality of life for patients affected by these complex type 2 inflammatory diseases.

Watch the Webinar: EGIDs and the Lungs

Presented by:

  • Pujan Patel,  Consultant in Respiratory Medicine at the Royal Brompton Hospital, London and Honorary Senior Clinical Lecturer at Imperial College London

Explore the connection between Eosinophilic Gastrointestinal Diseases (EGIDs) and type 2 inflammatory respiratory conditions, including eosinophilic asthma, general asthma, chronic rhinitis, and other multi-system diseases.

hands with paper intestines representing eosinophilic gastrointestinal diseases

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Key Topics Covered:

  1. What are eosinophilic diseases
  2. Understanding an overlap between EGIDs and lung conditions
  3. Eosinophilic Oesophagitis (EoE) and asthma
  4. What is asthma? Common symptoms
  5. Challenges of diagnosing asthma: typical symptoms and diagnostic tools
  6. Peak Flow Variability meter
  7. Lung function testing
  8. Fractional Exhaled Nitric Oxide (FENO)
  9. Common asthma mimics
  10. Sputum eosinophil-guided asthma therapy: study results
  11. Risk of asthma exacerbation and blood eosinophil count
  12. FENO levels and asthma exacerbations risk
  13. Asthma diagnosis, treatment & management guidelines
  14. Severe asthma patients and healthcare costs for uncontrolled eosinophilic asthma
  15. Harms of cumulative oral corticosteroid (OCS) exposure: study results
  16. Biologic therapies: omalizumab, dupilumab and others
  17. Real-world impact of the biologic treatments
  18. Asthma services structure (the UK)
  19. Eosinophilic Granulomatosis with Polyangitis (EGPA), previously Churg-Strauss Syndrome (CSS): clinical manifestations, diagnosis and management
  20. The gut-lung axis

Additional Resources

What is Eosinophil?

Understanding Clinical Trials 

Biologics for Eosinophilic Diseases: Latest News & Research

Burden of Oral Corticosteroids in Severe Asthma: Key Takeaways from a 2025 Review

Eosinophilic Oesophagitis and Asthma: A Revealing Connection in Hospital Visits

Benralizumab for Eosinophilic Asthma and COPD Exacerbations. ABRA Study Findings

Persistent Asthma Symptoms in Children on Mepolizumab


This resource was developed with support from the National Lottery Community Fund.