Researchers at CEGIR have developed the Index of Severity for Eosinophilic Esophagitis (I-SEE) to help reach an international consensus on the severity of the disease.

There's still a lot of variance in how healthcare practitioners determine EoE severity, which affects decisions about treatment and management.

The I-SEE scoring system can be completed at routine clinic visits and will help guide practitioners by standardising care, as well as improving benchmarking in future clinical studies.


A multidisciplinary international group of adult and paediatric EoE researchers and clinicians, as well as non-EoE allergy immunology and gastroenterology experts, formed 3 teams to review the existing literature on histology, endoscopy, and symptoms of EoE in the context of progression and severity.

A steering committee convened a 1-day virtual meeting to reach consensus on each team’s opinion on salient features of severity across key clinicopathologic domains and distill features that would allow providers to categorize disease severity.

Symptom features and complications and inflammatory and fibrostenotic features on both endoscopic and histologic examination were collated into a simplified scoring system, the I-SEE, that can be completed at routine clinic visits to assess disease severity using a point scale of 0–6 for mild, 7–14 for moderate, and ≥15 for severe EoE.

I-SEE tool for practitioners in EoE management

To read the full research paper published in Gastroenterology, click the link below. The I-SEE table is Table 1 in the paper.