Findings from a review of the screening data for the recently-published ENIGMA study adds evidence to the under-diagnosis of eosinophilic gastritis (EG) and eosinophilic gastroenteritis (EGE, also known as eosinophilic duodenitis EoD).

The ePoster is available on the ePoster Hall website (P2797). In addition, the poster abstract (S1330) appears in the supplement to the October 2020 issue of the American Journal of Gastroenterology with the following commentary from authors:

There is growing evidence that EG/EGE is under-diagnosed, and that the true US prevalence may be higher than 50,000. Among moderate-severely symptomatic patients without known history of EG/EGE who entered screening for ENIGMA, 58% met histologic criteria for EG/EGE.

EGD with multiple systematic gastric and duodenal biopsies of patients with chronic non-specific GI symptoms, including those with functional GI conditions, may demonstrate a higher prevalence of EG/EGE than is currently estimated

Of the 113 patients who entered screening for ENIGMA study, 51 had no prior history of EG/EGE, 26 (51%) of whom met symptom criteria then underwent screening endoscopy. Of these 26 symptomatic patients, 15 (58%) met histologic criteria for EG/EGE, 13 of whom were randomised in the study. It is important to note these 13 patients, previously given functional GI diagnoses, were clinically similar in constellation and magnitude of symptoms compared to the 52 randomised patients with previously established EG. 


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